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Daily Cancer News  -  25 Mar 2008
Cancer Consultants,Thrombocytopenia is a major cause of morbidity and mortality in patients receiving chemotherapy for malignancy. Thrombopoetin (TPO) or thrombopoetin-like

Updates in the Management of Myelodysplastic Syndromes  -  25 Mar 2008
Cancer Consultants,The investigators found that patients experiencing treatment-related thrombocytopenia, regardless of baseline platelet counts, were more likely to achieve

Daily Cancer News  -  25 Mar 2008
Cancer Consultants,This regimen was described as well tolerated except for thrombocytopenia. A European randomized trial compared a regimen of irinotecan and carboplatin with

Eltrombopag in Thrombocytopenia  -  Mar 5, 2008
New England Journal of Medicine (subscription),Its application in treating interferon-induced thrombocytopenia, however, necessitates that it improve the sustained virologic response.

Amgen: Data Should Lead To FDA OK Of Romiplostim By 2Q  -  Mar 12, 2008
CNNMoney.comAmgen Inc. (AMGN), responding to a Food and Drug Administration committee meeting about its romiplostim drug for treating thrombocytopenia, said it believes

Publication of Clinical Results Underscores Velcade (Bortezomib ...  -  Mar 13, 2008
PharmaLive.com (press release),The safety profile of VcMP was as expected based on the known safety profile of each of the individual agents in the combination, including thrombocytopenia

FDA panel backs Amgen drug for blood disorder  -  Mar 12, 2008
Reuters...advisers said the benefits of the injectable drug, called Nplate, outweighed the risks for treating chronic immune thrombocytopenia purpura, or ITP.

US FDA staff wants input on Amgen clot drug risks  -  Mar 10, 2008
Reuters UK,Amgen is seeking FDA approval to sell Nplate for adults with a clotting disorder called chronic immune thrombocytopenia purpura, or chronic ITP.

Amgen To Discuss Biologic License Application For Romiplostim At ...  -  Mar 12, 2008
RTT News,The proposed indication for romiplostim submitted to the FDA is for the treatment of thrombocytopenia in adult patients with chronic ITP who have not

FDA Committee Recommends Approval for Amgen’s Platelet Generator  -  Mar 13, 2008
FDA news (subscription),Other risks include blood clots, immunogenicity and thrombocytopenia recurrence after therapy stops. The drug also may increase the proportion of blast

Amgen To Discuss Romiplostim Application At FDA ODAC Meeting ...  -  Mar 12, 2008
RTT News,Orphan drug romiplostim is reviewed as a potential drug for the treatment of thrombocytopenia in adult patients with chronic immune thrombocytopenic purpura

Perioperative Eloxatin Regimen Reduced Risk Of Relapse In ...  -  Mar 24, 2008
eMaxHealth.com,...sensory neuropathy (Grade 3: 9.6%), thrombocytopenia (Grade 3: 7.0%), infection (Grade 3: 6.0%), hepatic (Grade 3: 5.2%), diarrhea (Grade 3: 5.2%),

Amgen Issues Statement On Successful Outcome Of Romiplostim Panel ...  -  Mar 12, 2008
Trading Markets (press release),Romiplostim is an investigational thrombopoietin mimetic peptibody for the treatment of thrombocytopenia in adult patients with chronic immune

Market highlights for next week: Texas Instruments to hold mid ...  -  Mar 8, 2008
BloggingStocksFDA Oncologic Drugs Advisory Committee Meeting on Amgen Inc.'s (NASDAQ: AMGN) BLA for NPLATE for treatment of thrombocytopenia at 8:00 am.

High-dose aprotinin effectively reduces blood loss during on-pump ...  -  Mar 18, 2008
The Journal of Thoracic and Cardiovascular SurgeryBivalirudin during cardiopulmonary bypass in patients with previous or acute heparin-induced thrombocytopenia and heparin antibodies: results of the

Fludarabine, Mitoxantrone and Zevalin(R) Produces 96% Complete ...  -  Mar 16, 2008
PR Newswire (press release),The most serious adverse reactions of the Zevalin therapeutic regimen were primarily hematologic, including neutropenia, thrombocytopenia, and anemia.

Effects of induction immunosuppression regimen on acute rejection ...  -  Mar 18, 2008
The Journal of Thoracic and Cardiovascular SurgeryAT was stopped for hypersensitivity, leukopenia, or thrombocytopenia. Daily triple maintenance immunosuppression included cyclosporine (INN ciclosporin) or

Amgen Statement on Successful Outcome of Romiplostim Panel Meeting  -  Mar 16, 2008
PR-Inside.com (Pressemitteilung),Patients with chronic ITP, a serious autoimmune disorder characterized by low platelet counts in the blood (thrombocytopenia) face the risk of bleeding

Extracorporeal membrane oxygenation support improves survival of ...  -  Mar 18, 2008
The Journal of Thoracic and Cardiovascular SurgeryEarly presumptive diagnosis of Hantavirus infection was strongly suspected by the presence of thrombocytopenia, hemoconcentration, myelocytosis,

Alexion Completes Enrollment In AEGIS Registration Study Of ...  -  Mar 22, 2008
Medical News Today (press release),...in a broad and diverse population of patients with PNH, including patients with minimal transfusion requirements and/or evidence of thrombocytopenia.

Anemia Drug Warning Extended as FDA Panel Prepares to Ponder  -  Mar 10, 2008
BioWorld Online,Amgen is seeking approval to sell the drug to treat chronic immune thrombocytopenia purpura. The news had little impact Monday on Thousand Oaks, Calif.

New Lung Cancer Guidelines Advise Adjuvant Therapy in Early Disease  -  Mar 10, 2008
Medscape (subscription)They also note that bevacizumab might not be an ideal choice to use with other regimens — particularly if the estimated risk for grade 4 thrombocytopenia is

Cephalon's Treanda gets FDA approval  -  Mar 21, 2008
The Money Times,The most common side effects were Neutropenia, fever, Thrombocytopenia, Nausea, Anemia, Leucopenia, and Vomiting. The American Cancer Society estimates,

FDA Grants Priority Review For Promacta / Revolade (Eltrombopag)  -  Mar 10, 2008
Medical News Today (press release),The compound is also being studied for long-term treatment of chronic ITP, as well as thrombocytopenia associated with Hepatitis C Virus cirrhosis and

New Drug Added to Arsenal Against CLL  -  Mar 20, 2008
Cancerpage.com,The most common side effects included neutropenia, fever, thrombocytopenia, nausea, anemia, leucopenia, and vomiting. The drug’s manufacturer, Cephalon,

FDA Okays Bendamustine (Treanda) for CLL  -  Mar 20, 2008
MedPage Today,The most common adverse events in the bendamustine group were neutropenia (28%), thrombocytopenia (23%), anemia (19%), leukopenia (18%), pyrexia (24%),

US FDA advisers back Amgen clot disorder drug  -  Mar 12, 2008
Guardian,...sell the drug for adults who have not responded to other treatments for a disorder called chronic immune, or idiopathic, thrombocytopenia purpura (ITP).

Amgen 'pleased' w/ FDA panel vote on Nplate drug; looks for ...  -  Mar 12, 2008
CNNMoney.com...to the company's proposed treatment for the autoimmune blood disorder thrombocytopenia in adult patients with chronic immune thrombocytopenic purpura.

Wednesday's Health Winners & Losers  -  Mar 12, 2008
TheStreet.com...unanimously voted to recommend approval for Nplate, a treatment of low platelet counts in patients with chronic immune thrombocytopenia purpura, or ITP.

Dengue panic in Brazil: 19.169 cases and 30 deaths in 2008  -  Mar 19, 2008
MercoPress,Symptoms include sudden onset of fever, severe headache, myalgias and arthralgias, leucopenia, thrombocytopenia and hemorrhagic manifestations.

US FDA staff seeks input on Amgen clot drug risks  -  Mar 10, 2008
Scientific AmericanAmgen is seeking FDA approval to sell the injectable drug for adults with a clotting disorder called chronic immune thrombocytopenia purpura, or chronic ITP

Vorinostat Promising in AML  -  Mar 19, 2008
Cancerpage.com,Grade 3/4 adverse events related to the drug included fatigue, thrombocytopenia and diarrhea. Twenty-nine patients dropped out of the study because of

Otsuka Pharmaceutical and PDL BioPharma Close Sale of IV Busulfex  -  Mar 10, 2008
CNNMoney.comAt the recommended dosage, IV Busulfex produced profound myelosuppression in all patients (ie, severe granulocytopenia, thrombocytopenia, anemia,

How to defeat a virus  -  Mar 19, 2008
Express Healthcare Management,IFN-alpha monotherapy is limited by adverse side effects such as severe flu-like syndrome, leucopoenia and thrombocytopenia.

HEALTHY LIFE: Saved by Leeches  -  Mar 18, 2008
KCRG,About 120000 patients each year have an allergy to heparin, known as heparin-induced thrombocytopenia, and neither they nor their doctor knows.

New Chronic Myelogenous Leukemia Guidelines Add Nilotinib  -  Mar 17, 2008
Medscape (subscription)Serious drug-related adverse reactions include thrombocytopenia, neutropenia, pneumonia, febrile neutropenia, leukopenia, intracranial hemorrhage,

New Guidelines for Management of Urinary Tract Infection in ...  -  Mar 17, 2008
Medscape (subscription)Adverse effects may include fever, rash, photosensitivity, neutropenia, thrombocytopenia, anorexia, nausea and vomiting, pruritus, headache, urticaria,

UPDATE 1-Glaxo wins FDA priority review for blood drug  -  Mar 3, 2008
Reuters UK,The drug is designed to treat idiopathic thrombocytopenia purpura (ITP), an autoimmune disease which results in low blood platelet counts.

Orthopedic Manifestations and Management of Patients With von ...  -  Mar 17, 2008
Ortho SuperSite,Complete blood count is appropriate to look for anemia resulting from chronic blood loss, as well as for the presence of thrombocytopenia (as in type 2B von

Hospira Launches Generic Irinotecan Injection  -  Feb 28, 2008
FOXBusinessCommon adverse events include diarrhea (early and late), neutropenia, leukopenia, anemia, thrombocytopenia, nausea, vomiting, abdominal cramping,

Baxter's heparin mystery unsolved  -  Mar 15, 2008
Food Consumer,The natural substance can cause some side effect, commonly known as heparin-induced thrombocytopenia (HIT syndrome). In the case of allergic reactions to

Blanket of snow helped detect Nikita’s health problem  -  Mar 14, 2008
Cape Breton Post,Michele could easily read the concern on my face and eagerly consented for some blood tests, which confirmed my suspicion of thrombocytopenia (low platelet

Combination Therapy Effective Against Multiple Myeloma  -  Mar 14, 2008
Cancerpage.com,..."The most common grade 3 or higher hematologic toxicities were neutropenia (19.4%), anemia (13.8%) and thrombocytopenia (22.2%).

Rigel Announces Participation in Upcoming Investor and Partnering ...  -  Mar 13, 2008
PR Newswire (press release),Rigel has product development programs in inflammatory/autoimmune diseases such as rheumatoid arthritis, thrombocytopenia and asthma, as well as in cancer.

Publication of Clinical Results Underscores VELCADE(R) (Bortezomib ...  -  Mar 13, 2008
SunHerald.com,The safety profile of VcMP was as expected based on the known safety profile of each of the individual agents in the combination, including thrombocytopenia

Signs and Symptoms of Hemolytic Uremic Syndrome  -  Mar 13, 2008
Informative Post,It is characterized by acute kidney failure, hemolytic anemia and thrombocytopenia. It is the most common cause of acute kidney failure in children.

Advisory Panel Urges FDA To Approve Amgen Drug, Nplate  -  Mar 12, 2008
dBTechno,It is a drug which treats a rare blood disorder called chronic immune thrombocytopenia purpura. This disorder causes brusing and bleeding following just

Chemotherapy Offers Little Benefit for Localized Stomach Cancer  -  Mar 12, 2008
MedPage Today,...mucositis (8.4%), diarrhea (11.8%), leucopenia (20.3%), anemia (3.3%), and thrombocytopenia (4.2%). The study was limited by underestimation of survival

Market Report -- In Play (WIRES)  -  Mar 12, 2008
MSN Money...for the treatment of thrombocytopenia in adult patients with chronic immune thrombocytopenic purpura today at the Oncologic Drugs Advisory Committee.

Nurse Group Moves to Educate Myeloma Patients  -  Mar 10, 2008
Nurse.com,...and constipation), thromboembolic events (deep vein thrombosis and pulmonary embolism) and myelosuppression (including thrombocytopenia, neutropenia,

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