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Updates in the Management of Myelodysplastic Syndromes  -  24 Mar 2008
Cancer Consultants,...and flu-like illness; serious osteonecrosis, febrile neutropenia, and thrombocytopenia (one patient each); and transient increase in blast percentage in

Osteonecrosis of the jaw and bisphosphonate use: How big a risk?  -  Mar 10, 2008
Endocrine Today,Until recently, osteonecrosis of the jaw had appeared in medical literature as no more than a curiosity, with little information on its cause or prevalence.

Chondrolysis, Osteonecrosis, and Slip Severity in Patients with ...  -  Mar 1, 2008
Journal of Bone and Joint Surgery (subscription)The purpose of this study was to identify the prevalence of chondrolysis and osteonecrosis and the degree of slip severity in contralateral hips with a

Fate of Untreated Asymptomatic Osteonecrosis of the Femoral Head  -  Mar 1, 2008
Journal of Bone and Joint Surgery (subscription)Background: Magnetic resonance imaging has made it possible to detect asymptomatic lesions of osteonecrosis of the femoral head before abnormalities appear

Arthritis and your Teeth  -  Mar 11, 2008
Cherry Creek News,Osteonecrosis is the break down and eventual collapse of bone resulting from the loss of blood supply to bone tissue. Symptoms may include pain,

SENIOR MOMENT: Fighting brittle bones  -  Mar 11, 2008
Southwest Virginia Today,Osteonecrosis is characterized by swelling of and pain in the jaw, loose teeth, and sliding of the skin away from the jawbone.

Other News Video  -  Feb 29, 2008
WSOCtv.com,Injury can lead to a decrease or interruption of blood supply to the bone, causing a part of the bone to die (called, osteonecrosis, or avascular necrosis).

Fosamax, Other Osteoporosis Drugs Linked to Bone Weakness  -  Mar 21, 2008
Newsinferno.com,Bisphosphonates have been linked to a variety of other safety problem, including Osteonecrosis of the Jaw (ONJ). Also known as Dead Jaw Syndrome,

Bone and Cancer Foundation Announces New Online Resource for ...  -  Mar 20, 2008
PR Leap (press release),The information is relevant for those who have or are treating breast cancer, prostate cancer, and osteonecrosis of the jaw (ONJ).

Stonegate Report About Unigene Laboratories Inc.  -  Mar 13, 2008
PR Newswire (press release),Since 2003, medical journal articles have suggested that long-term use of bisphosphonates could lead to osteonecrosis of the jaw (ONJ).

Hypertension and diabetes can cause kidney disease  -  Mar 12, 2008
Northern Daily News,If you have cancer, existing dental disease or poor dental hygiene, you may be at a higher (but still minimal) risk of developing osteonecrosis of the jaw.

Boning up on New Osteoporosis Risk Guidelines  -  Mar 10, 2008
Business Wire (press release),However, recent reports have associated bisphosphonates with osteonecrosis (â€œbone deathâ€?) of the jaw, severe bone/joint pain and potentially severe

MRI Not Required for Knee Osteoarthritis, Study Suggests ...  -  Mar 7, 2008
DG News...localised tenderness, that can look normal on a radiograph. In such cases, MRI can be useful to diagnose spontaneous osteonecrosis or a stress fracture.

AAOS: MRI Overused in Knee Replacement Surgery  -  Mar 6, 2008
MedPage Today,..."In this case, MRI can be useful to diagnose spontaneous osteonecrosis of the knee or a stress fracture," he said. Although lack of musculoskeletal

Does alendronate prevent fractures after the menopause?  -  Mar 6, 2008
Pulse,However, observational data raises concerns regarding risk for upper GI injury and, less commonly, osteonecrosis of the jaw. At a dose of 10mg per day,

Musher in wheelchair realizes dream trip  -  Mar 2, 2008
Anchorage Daily News (subscription),During physical therapy they found I had osteonecrosis, which is bone death, in my hip. My hip was disintegrating. Finally, after two years of pain and

Bone drugs iffy  -  Mar 2, 2008
Toronto Sun,...reports that osteoporosis drugs (prescribed to strengthen thinning bones) can trigger osteonecrosis (destruction of bone, in particular the jaw).

Hemiarthroplasty for the Rotator Cuff-Deficient Shoulder  -  Mar 1, 2008
Journal of Bone and Joint Surgery (subscription)Patients with a diagnosis of rheumatoid or inflammatory arthritis, osteonecrosis, fracture, fracture malunion, or fracture nonunion were excluded.

P&G wins patent infringement lawsuit for osteoporosis therapy Actonel  -  Feb 29, 2008
Prdomain Business Register (press release),Rare occurrences of osteonecrosis, primarily of the jaw (ONJ), have been reported in patients receiving bisphosphonates. Most ONJ cases have occurred in

Fossy jaw risk lower with oral meds  -  20 Feb 2008
ArabianBusiness.com,In 2003, case reports linked intravenous bisphosphonate treatment with osteonecrosis of the jaw. Subsequent studies confirmed this association.

FDA Posts MedWatch Side Effect Alert for Osteoporosis Drugs  -  20 Feb 2008
Natural News.com,Bisphosphonates are also linked to osteonecrosis (destruction of jawbone tissue) and are currently being assessed by the FDA for the potential to cause

Bisphosphonates and Osteonecrosis of the Jaw  -  Feb 19, 2008
Irish Medical Times,This review concluded that the occurrences of osteonecrosis of the jaw were positively associated with the potency of the bisphosphonate used and were

Bilateral Osteonecrosis of the Femoral Head Associated with ...  -  Feb 15, 2008
Ortho SuperSite,Osteonecrosis is thought to result from the temporary or permanent loss of the blood supply to the bones. 1,2 This disease is also known as avascular

Treating Osteoporosis With Bisphosphonates And Incidence Of Bone ...  -  Feb 16, 2008
Science Daily (press release)In 2003, the first reports emerged of a "new" disease, called osteonecrosis of the jaw (ONJ), found in patients who were using BFs.

There may be no bisphosphonates, ONJ link  -  Feb 18, 2008
United Press International18 (UPI) -- A US study of more than 7000 patients found the use of bisphosphonates to treat osteoporosis has little effect on osteonecrosis of the jaw,

Autogenous Osteochondral Transfer in the Femoral Head After ...  -  Jan 31, 2008
Ortho SuperSite,A 36-year-old man developed bilateral hip pain in 1998 and was diagnosed with bilateral osteonecrosis of the femoral head. The patient had a history of

Aastrom Biosciences Announces Transition of Duties  -  Feb 15, 2008
CNNMoney.com (press release)Aastrom product candidates to treat osteonecrosis of the femoral head and dilated cardiomyopathy have been designated for orphan drug status by the FDA.

Trouble Brews Over Merck Product  -  Jan 30, 2008
Wall Street JournalA growing number of patients allege the bone-strengthening drug causes a bone-wasting condition called osteonecrosis of the jaw, or ONJ.

Gender Specific Hips  -  Feb 18, 2008
WHOI,Injury can lead to a decrease or interruption of blood supply to the bone, causing a part of the bone to die (called, osteonecrosis, or avascular necrosis).

Suit Alleges More Health Problems From Merck's Fosamax Drug  -  Jan 28, 2008
Wall Street JournalMore than 400 people already have sued Merck alleging that Fosamax causes a bone-wasting condition known as osteonecrosis of the jaw.

Aastrom Reports Second Quarter Fiscal Year 2008 Financial Results  -  Feb 8, 2008
FOXBusinessEarly clinical results were presented from the first use of Aastrom's Bone Repair Cells (BRCs) to treat four patients suffering from osteonecrosis of the

Osteoporosis is traditionally thought of as a women's disease ...  -  Feb 18, 2008
PR-Inside.com (Pressemitteilung),These conditions may include osteonecrosis of the jaw and the occurrence of sudden fractures that do not heal normally." Unigene Laboratories has developed

Expanded use of osteo drugs questioned  -  Jan 22, 2008
ABC Science Online,...of side effects are simply not successful." He says cases of Alendronate causing osteonecrosis of the jaw are extremely rare affecting 1 in 100000 people.

Osteoporosis Drugs May Be Overused  -  Jan 22, 2008
Sci-Tech Today..."The risk of getting osteonecrosis of the jaw is about the same as getting struck by lightning," said Dr. Norman Watts, director of bone health and

Adjuvant Therapy for HER2-Normal Early-Stage Breast Cancer  -  Feb 4, 2008
Medscape (subscription)However, among the ZA-treated patients, 1 possible and 2 confirmed cases of osteonecrosis of the jaw, a rare but known complication of bisphosphonate

Abbott's Kaletra(R) and Aluvia(R) (lopinavir/ritonavir) New Lower ...  -  Jan 28, 2008
CNNMoney.comSome patients taking combination antiretroviral therapy may develop a bone disease called osteonecrosis. Signs and symptoms are joint stiffness,

Polyethylene Acetabular Component Insertion During Total Hip ...  -  Feb 5, 2008
The Open Press (press release)...acetabular component used in total hip arthroplasties with cemented expansion acetabular component for advanced osteonecrosis of the femoral head.

The Long Case for Unigene Laboratories  -  Feb 5, 2008
Seeking Alpha,Not to mention the other disastrous side effects like osteonecrosis of the jaw where already hundreds of law suits have been filed or the heart rhythm

Regenerative Therapies: the Slow Move From Horses to Humans  -  Feb 1, 2008
Methuselah Foundation,...such as osteoarthritis of the knee, fractures that wonâ€™t heal, and bone degeneration of the hip and other joints, known as osteonecrosis or avascular

Displacement/Screw Cutout After Open Reduction and Locked Plate ...  -  Feb 1, 2008
Journal of Bone and Joint Surgery (subscription)...screw cutout with intra-articular displacement in twelve (23%), substantial (>10Â°) varus displacement in thirteen (25%), and osteonecrosis in two (4%).

Treatment of Intertrochanteric Nonunion of the Proximal Femur ...  -  Jan 31, 2008
Ortho SuperSite,Patients were excluded if the fracture involved the femoral neck or if failure was the result of osteonecrosis, infection, or an etiology other than

Supracondylar Correction Osteotomy to Prevent Repetitive Posterior ...  -  Jan 31, 2008
Ortho SuperSite,4 Secondary osteonecrosis of the femoral head developed, and 2 years later, the patient underwent THR. Following THR, a chronic low-grade infection

Another Fosamax Lawsuit  -  Jan 29, 2008
Newsinferno.com,Another 400 plaintiffs have Fosamax lawsuits pending that allege the bone medication caused a bone-wasting condition known as osteonecrosis of the jaw (ONJ)

Systematic review shows alendronate significantly reduces ...  -  Jan 24, 2008
Ortho SuperSite,However, observational data raise concerns regarding the potential risk for upper gastrointestinal injury and, less commonly, osteonecrosis of the jaw,"

Abbott's Kaletra(R) and Aluvia(R) (lopinavir/ritonavir) New Lower ...  -  Jan 28, 2008
Juraforum.de,Some patients taking combination antiretroviral therapy maydevelop a bone disease called osteonecrosis. Signs and symptoms arejoint stiffness,

Patients urged to keep bone medication  -  Dec 17, 2007
Melbourne Herald Sun,In Australia, about 200 cases of osteonecrosis of the jaw had been detected, and "only a handful" were osteoporosis patients, Prof Sambrook said.

Regulator acts on risk alert for bone drugs  -  Dec 14, 2007
The Australian,They are intended to increase bone density but in rare cases can interfere with normal bone healing in the jaw -- a condition called osteonecrosis,

Watchdog under fire over 'dead jaw' drug fears  -  Dec 11, 2007
ABC Online,Last night ABC TV's The 7.30 Report revealed that increasing numbers of Australians are falling victim to a side effect known as osteonecrosis of the jaw.

Worrying drug side effects: death of the jawbone  -  Dec 11, 2007
ABC Online,It's called osteonecrosis of the jaw. Literally death of the jawbone, and as its name suggests, it's causing horrific damage to people's mouths and in at

Aastrom Biosciences to Present At BMO Capital Markets Healthcare ...  -  Nov 29, 2007
CNNMoney.comCurrently, the company has a bone regeneration product in Phase III development for the treatment of osteonecrosis of the femoral head (called the ON-CORE

Drug makers react to 'dead jaw' concerns  -  Dec 11, 2007
ABC Online,Oral surgeon Dr John Hennessy says he has seen a steady increase in the number of patients with "dead jaw" or osteonecrosis. "What occurs is widespread

Aastrom Biosciences Receives Notice Related to NASDAQ Minimum ...  -  Dec 21, 2007
CNNMoney.comAastrom product candidates to treat osteonecrosis of the femoral head and dilated cardiomyopathy have been designated for orphan drug status by the FDA.

Letter: Drug carries side effects  -  Nov 30, 2007
Enterprise-Record,About a year ago, I read an article about a condition called "osteonecrosis," or deterioration of the jaw. I stopped taking Fosomax immediately but with

No Easy Choice for Fracture Prevention Agents  -  Dec 20, 2007
MedPage Today,Despite several reports of osteonecrosis of the jaw with high-dose, intravenous bisphosphonates, the investigators could not calculate the risk overall.

Surgical options for the painful hip in young adults  -  Dec 5, 2007
Ortho SuperSite,If plain films document the preservation of joint space, we most often obtain an MRI arthrogram to rule out both osteonecrosis and other chondral and

SABCS: AI Bone Loss Significantly Less With Zometa  -  Dec 14, 2007
PharmaLive.com (press release),To date, there have been no confirmed cases of osteonecrosis of the jaw reported as part of the Z-FAST trial. Zometa is indicated for the treatment of

'Jaw death' suit filed against Merck  -  Dec 13, 2007
Southeast Texas Record,By taking Fosamax the plaintiffs claim they developed osteonecrosis of the jaw, the suit said. Better known as "jaw death," osteonecrosis of the jaw is a

Doctors angered by ABC report on bone drugs  -  Dec 18, 2007
The Australian,Grimm - stated that so-called bisphosphonate drugs can cause the jaw bone to dissolve, a disfiguring condition called osteonecrosis of the jaw, or ONJ.

ASK DR. WEIL Beware of drugs for bone boosting  -  Dec 16, 2007
Houston Chronicle,Dentists have observed that some patients on these drugs are at risk of developing an untreatable condition called osteonecrosis of the jaw (ONJ),

Index to Web Commentaries for 2007  -  Dec 3, 2007
Journal of Bone and Joint Surgery (subscription)...(2007;89:987-93) Marvin E. Steinberg, MD, on "Current Practices of AAHKS Members in the Treatment of Adult Osteonecrosis of the Femoral Head" by McGrory et

'Dead jaw' concerns over cancer drugs  -  Dec 11, 2007
NEWS.com.au,An estimated 500 Australians have developed the condition named osteonecrosis of the jaw (ONJ) over the past four years, linked to their prescribed use of

Fosamax Users Seek Class-Action Status  -  Dec 1, 2007
The Associated Press...by users who believe the drug caused osteonecrosis of the jaw, a condition in which portions of the jaw bone die, sometimes leaving the bone exposed.

Unigene States That New Government Study Reports That Many ...  -  Dec 19, 2007
Business Wire (press release),Additionally, certain bisphosphonates have been associated with osteonecrosis. Separately, the FDA is currently conducting a safety review of all

Denosumab Effective in Treating Bone Loss Induced by Aromatase ...  -  Dec 17, 2007
Cancer Consultants (press release),...however, most bisphosphonates require intravenous administration and may cause renal complications as well as osteonecrosis of the jaw.

Zoledronic Acid Markedly Effective Against MGUS Bone Loss ...  -  Dec 13, 2007
DG NewsNo patients sustained new fractures or osteonecrosis of the jaw during the trial. One patient developed chronic lymphocytic leukemia during treatment.

New Data Show Glivec Halts Progression to Advanced Stages of Life ...  -  Dec 10, 2007
PharmaLive.com (press release),...eye, kidney and gastrointestinal tract), diverticulitis, gastrointestinal perforation, tumor hemorrhage/ necrosis, hip osteonecrosis/avascular necrosis.

Persistent Hypocalcemia Induced By Zoledronic Acid In A Patient ...  -  Dec 2, 2007
Medical News Today (press release),UroToday.com - Many physicians are aware of well-publicized side effects of intravenous bisphosphonates such as renal dysfunction and osteonecrosis of the

Nilotinib Response Rates Continue To Improve In Patients With ...  -  Dec 13, 2007
Medical News Today (press release),...kidney and gastrointestinal tract), diverticulitis, gastrointestinal perforation, tumour haemorrhage/ necrosis, hip osteonecrosis/avascular necrosis.

Osteoporosis: An Equal Opportunity Illness  -  Nov 30, 2007
Medical News Today (press release),These conditions may include osteonecrosis of the jaw and the occurrence of sudden fractures that do not heal normally." Unigene Laboratories has developed

Ugandan Children Are Among the First to Receive Abbott's Lower ...  -  Dec 1, 2007
PR Newswire UK (press release),Some patients taking combination antiretroviral therapy may develop a bone disease called osteonecrosis. Signs and symptoms are joint stiffness,

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