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Updates in the Management of Myelodysplastic Syndromes  -  25 Mar 2008
Cancer Consultants,For those without baseline neutropenia, those with treatment-related neutropenia were more likely to respond to therapy (82% vs. 51%, p=0.02), though for

Advances in the Management of Advanced Non-Small Cell Lung Cancer  -  25 Mar 2008
Cancer Consultants,A previous study has shown that pemetrexed has less toxicity, including significantly lower incidence of neutropenia and neutropenic fever, than docetaxel

Daily Cancer News  -  25 Mar 2008
Cancer Consultants,There have been seven cases of febrile neutropenia (25%) but no toxic deaths. In light of advances with targeted therapies in other tumor types,

Neutropenia More Costly than Thought  -  Mar 19, 2008
Cancer Consultants,Neutropenia is an abnormally low white blood cell count, a potential side effect of chemotherapy. White blood cells (neutrophils) are a vital part of the

Function Of Molecular Switch Pinpointed In Severe Congenital ...  -  Mar 6, 2008
Science Daily (press release)6, 2008) — Researchers have for the first time cleared an important hurdle to clarifying the molecular mechanics behind Severe Congenital Neutropenia (SCN),

Perioperative Eloxatin Regimen Reduced Risk Of Relapse In ...  -  Mar 24, 2008
eMaxHealth.com,The most common adverse events seen with pre-operative FOLFOX4 include: neutropenia (Grade 3/4: 18.1%), diarrhea (Grade 3: 8.2%), stomatitis/pharingitis

Neulasta® on First Day of Chemotherapy May Be More Convenient for ...  -  Mar 17, 2008
Cancer Consultants,Unfortunately, chemotherapy is associated with side effects, such as low levels of immune cells—a condition referred to as neutropenia.

HIV-1 infection greatly increased the risk of neutrophil depletion ...  -  Mar 11, 2008
Aidsmap,HIV-infected Uganda children had over seven times the risk of neutrophil depletion (neutropenia) while receiving antimalarial treatment compared to Ugandan

Neose to advance PEG products in 2008  -  Mar 12, 2008
In-PharmaTechnologist.com,Vergis said that Neose's development of the neutropenia treatment GlycoPEG-GCSF, which is being carried out in partnership with Germany's BioGeneriX,

Children's tracks leukemia genes  -  Mar 7, 2008
Cincinnati Enquirer,Researchers led by H. Leighton Grimes also designed a mouse with the two genes so they can further study the development of severe congenital neutropenia,

SGO: Same-Day Administration of Pegfilgrastim Favored in Chart Review  -  Mar 13, 2008
MedPage Today,...to delay the start of pegfilgrastim until 24 hours after cytotoxic therapy leads to more prolonged and severe neutropenia and more febrile neutropenia.

Performance of Interleukin-6 and Interleukin-8 serum levels in ...  -  Mar 6, 2008
BMC Pediatrics,Patients with chemotherapy-related neutropenia and fever are usually hospitalized and treated on empirical intravenous broad-spectrum antibiotic regimens.

Genta Licenses Daiichi Sankyo Oncology Drug on Clinical Hold  -  Mar 14, 2008
FDA news (subscription),...a drug placed on clinical hold by the FDA after severe neutropenia led to fatal outcomes in several patients with advanced cancer.

Genta Announces Licensing Agreement for Worldwide Development and ...  -  Mar 7, 2008
Biloxi Sun Herald,The major side-effect of tesetaxel in clinical trials has been myelosuppression, chiefly neutropenia. Due to the occurrence of severe neutropenia that led

Publication of Clinical Results Underscores Velcade (Bortezomib ...  -  Mar 13, 2008
PharmaLive.com (press release),VELCADE is associated with thrombocytopenia and neutropenia. There have been reports of gastrointestinal and intracerebral hemorrhage in association with

Fludarabine, Mitoxantrone and Zevalin(R) Produces 96% Complete ...  -  Mar 16, 2008
PR Newswire (press release),Febrile neutropenia occurred in 9 percent (5 of 57) of patients. Patients who relapsed were treated with CHOP + rituximab as salvage therapy and all

Cephalon wins US approval for leukemia drug  -  Mar 20, 2008
Guardian,Neutropenia, a drop in white blood cells that can make patients vulnerable to infections, occurred in 28 percent of Treanda patients compared with 14

New Chronic Myelogenous Leukemia Guidelines Add Nilotinib  -  Mar 17, 2008
Medscape (subscription)Serious drug-related adverse reactions include thrombocytopenia, neutropenia, pneumonia, febrile neutropenia, leukopenia, intracranial hemorrhage,

Hospira Launches Generic Irinotecan Injection  -  Feb 28, 2008
FOXBusinessCommon adverse events include diarrhea (early and late), neutropenia, leukopenia, anemia, thrombocytopenia, nausea, vomiting, abdominal cramping,

AstraZeneca Submits sNDA for SEROQUEL XR(TM) for the Treatment of ...  -  Feb 29, 2008
PR Newswire (press release),Patients with a pre-existing low white blood cell (WBC) count or a history of drug induced leukopenia/neutropenia should have their complete blood count

Tocilizumab (Actemra) Found Effective in RA and Juvenile ...  -  Mar 21, 2008
MedPage Today,Serious adverse events included anaphylactoid reaction, gastrointestinal hemorrhage, infectious mononucleosis, neutropenia, and Herpes zoster.

Positive CHMP Opinion For Histologically-Based Use Of ALIMTA(R ...  -  Feb 26, 2008
Medical News Today (press release),Haematological: Very common: Anaemia, leucopenia, thrombocytopenia, neutropenia. Common: Febrile neutropenia and infection without neutropenia.

Neose Technologies Q4 2007 Earnings Conference Call  -  Mar 10, 2008
Seeking Alpha,Clinical end points will include the duration of severe neutropenia and the incidence of febrile neutropenia as well as safety and tolerability.

Cephalon's Treanda gets FDA approval  -  Mar 21, 2008
The Money Times,The most common side effects were Neutropenia, fever, Thrombocytopenia, Nausea, Anemia, Leucopenia, and Vomiting. The American Cancer Society estimates,

New Drug Added to Arsenal Against CLL  -  Mar 20, 2008
Cancerpage.com,The most common side effects included neutropenia, fever, thrombocytopenia, nausea, anemia, leucopenia, and vomiting. The drug’s manufacturer, Cephalon,

FDA Okays Bendamustine (Treanda) for CLL  -  Mar 20, 2008
MedPage Today,The most common adverse events in the bendamustine group were neutropenia (28%), thrombocytopenia (23%), anemia (19%), leukopenia (18%), pyrexia (24%),

CHOP-Zevalin(R) Investigational Regimen Produces 95% Complete ...  -  Mar 4, 2008
PR Newswire (press release),The most serious adverse reactions of the Zevalin therapeutic regimen were primarily hematologic, including neutropenia, thrombocytopenia, and anemia.

Chemotherapy With Chemoradiation For Pancreatic Cancer Has Small ...  -  Mar 4, 2008
Science Daily (press release)4) was 1 percent in the fluorouracil group and 14 percent in the gemcitabine group without a difference in neutropenia (a blood disorder) or infection.

Treatment Combo for Pancreatic Cancer Has Limited Benefit  -  Mar 4, 2008
Washington Post,There were no differences in neutropenia (a blood disorder), infection, or in the ability to complete chemotherapy or radiation therapy.

Maxygen's general counsel leaving Silicon Valley / San Jose ...  -  Mar 4, 2008
Bizjournals.com,Maxygen seeks drugs for hemophilia, rheumatoid arthritis, and neutropenia. The company also promoted Grant Yonehiro to chief business officer -- he's worked

Cell Therapeutics, Inc. (CTI) Submits European Marketing ...  -  Mar 4, 2008
FOXBusiness...meaningful toxicities, such as severe neutropenia and infection, and in the requirement for transfusions and use of hematopoietic growth factor support.

Save my son plea by father  -  Mar 3, 2008
Gulf Daily News,Abdulaziz was diagnosed with the blood disorder cyclic neutropenia when he was six months old and is plagued by recurrent infections.

New Guidelines for Management of Urinary Tract Infection in ...  -  Mar 17, 2008
Medscape (subscription)Adverse effects may include fever, rash, photosensitivity, neutropenia, thrombocytopenia, anorexia, nausea and vomiting, pruritus, headache, urticaria,

Abraxis Bioscience Announces Filing of Marketing Application in ...  -  Mar 17, 2008
Business Wire (press release),...cancer study for which FDA approval was based included neutropenia, anemia, infections, sensory neuropathy, nausea, vomiting and myalgia/arthralgia.

Key Step In Programmed Cell Death Discovered  -  Mar 1, 2008
SlashdotOn the flip side, deficiencies in Hax1 results in blood cells dying early, causing a disease called severe congenital neutropenia. by !ramirez (106823) "A

ReachBio Partners with Axiogenesis to Distribute Novel Cell-Based ...  -  Feb 27, 2008
FOXBusiness...drug compounds -- kinase inhibitors, for example -- can exhibit both cardiac toxicity and bone marrow toxicity such as myelosuppression or neutropenia.

Refractory Ovarian Cancers Respond to Experimental SNS-595 ...  -  Mar 14, 2008
DG News..."The rate of febrile neutropenia in this study is low (9%), indicating that SNS-595 is a generally well-tolerated drug in this population," he said.

Combination Therapy Effective Against Multiple Myeloma  -  Mar 14, 2008
Cancerpage.com,..."The most common grade 3 or higher hematologic toxicities were neutropenia (19.4%), anemia (13.8%) and thrombocytopenia (22.2%).

Adding Chemotherapy To Chemoradiation And Surgery For ...  -  Mar 14, 2008
Medical News Today,There was no difference in frequency in neutropenia between the two groups, nor were there differences in their abilities to complete chemotherapy or

Intensifying Treatment With Paclitaxel and Carboplatin Does Not ...  -  Mar 13, 2008
DG NewsThe predominant toxicity causing dose modification was neutropenia. Median time to progression was 17.5 months and median overall survival was 63.6 months,

Welichem Receives Additional Contribution from NRC-IRAP to ...  -  Mar 13, 2008
Canada NewsWire (press release),Additional positive tests could lead to a full drug development program for this compound's anti-cancer and anti-neutropenia (a condition with reduced

Publication of Clinical Results Underscores VELCADE(R) (Bortezomib ...  -  Mar 13, 2008
SunHerald.com,...based on the known safety profile of each of the individual agents in the combination, including thrombocytopenia, neutropenia and peripheral neuropathy.

Genta Incorporated Announces Fourth Quarter and Year End 2007 ...  -  Mar 12, 2008
Earthtimes,Due to the occurrence of several fatalities related to neutropenia, the drug is currently on clinical hold in the US Based upon guidance from FDA,

SGO: Dactinomycin Offers New Standard for Gestationa  -  Mar 11, 2008
MedPage Today,...in a similar proportion of patients in both treatment arms. The only grade 4 toxicity was one case each of neutropenia and anemia in the dactinomycin group.

Maxygen to Present at the Cowen & Company 28th Annual Health Care ...  -  Mar 11, 2008
PR Newswire (press release),The company's lead program, MAXY-G34, is designed to be an improved version of long-acting G-CSF for the treatment of neutropenia. MAXY-G34 is currently in

Neose Technologies Reports Fourth Quarter and Year End 2007 ...  -  Mar 11, 2008
PharmaLive.com (press release),The lead candidates in its pipeline, GlycoPEG-GCSF for chemotherapy-induced neutropenia, and the GlycoPEGylated hemostasis compounds Factor VIIa,

Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2007 ...  -  Mar 11, 2008
Earthtimes,SNS-595 has been generally well tolerated in this trial, with a low rate of febrile neutropenia or other Grade 3/4 adverse events and manageable Grade 1/2

Amgen's drug Nplate raises FDA's concerns over adverse reactions  -  Mar 10, 2008
Pravda,Amgen Inc. (NASDAQ: AMGN, SEHK: 4332), an international biotechnology company famous for its drugs against anemia, arthritis and neutropenia, uncovers its

FDA Grants Accelerated Approval of Avastin in Combination with ...  -  Mar 10, 2008
Hispanic PR Wire (press release),...reversible posterior leukoencephalopathy syndrome (RPLS), neutropenia and infection, nephrotic syndrome and congestive heart failure.

Sunesis Pharmaceuticals Reports Positive Interim Data for SNS-595 ...  -  Mar 10, 2008
Earthtimes,There was a low rate of febrile neutropenia or other Grade 3/4 adverse events, and manageable Grade 1/2 nausea or vomiting. Based on the indications of

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