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Blackpool help for Third World orphan  -  Mar 5, 2008
Blackpool Gazette,He had already had the prosthetic fitted at the Bispham-based service, in 2005, after being born with a condition known as microphthalmia – or a "shrunken"

ArQule Enrolls First Patient in Phase 1/2 Clinical Trial Program ...  -  Mar 13, 2008
Business Wire (press release),ARQ 197 is also currently being evaluated in Phase 2 clinical trials in MiT (Microphthalmia Transcription Factor)-driven tumors, which include clear cell

Two families in need of help  -  Mar 6, 2008
Middletown Journal,Conrad, 21, was born with microphthalmia, a defect that left her with no eyes. Since she never has walked, Conrad uses a wheelchair, and now her parents

Fighting freckles  -  20 Feb 2008
Malaysia Star,...endothelin-1 (a major protein that directly governs the stimulation of melanocyes), microphthalmia transcription Factor (MIFT – a mediator in the

A&M's Small Animal Clinic treats blind Great Pyrenees  -  Feb 17, 2008
Texas A&M The Battalion,She said that his condition is called microphthalmia - a case in which a dog's eyes are too small to function - and it was congenital.

ArQule Receives $3 Million Milestone from Kyowa Hakko  -  Feb 6, 2008
FOXBusinessIn the US, the Company has initiated a Phase 2 clinical program with this compound that includes ongoing trials in MiT (Microphthalmia Transcription

ArQule Reports Fiscal 2007 Year End and Fourth Quarter Results  -  Feb 7, 2008
Business Wire (press release),...“Patient enrollment is ongoing in the first two trials within that program, which target MiT (Microphthalmia Transcription Factor) tumors and pancreatic

arqule initiates phase ii trials for treatment of cancer  -  Nov 2, 2007
Pharmaceutical Business Review...by staff writer the primary objective of the microphthalmia transcription factor tumors trial is to determine the overall response rate in patients treated

arqule announces initiation of two phase 2 trials with c-met ...  -  Oct 31, 2007
Business Wire (press release),...an orally administered, small molecule inhibitor of the c-met receptor tyrosine kinase, in patients with mit (microphthalmia transcription factor)

Victims of fungicide receive payout  -  Aug 12, 2007
Scotsman,Attenborough said his son Jonathan was diagnosed with microphthalmia, in which his eye sockets failed to fully develop before birth, after his mother,

Prenatal Diagnosis of Isolated Laryngeal Atresia  -  Aug 22, 2007
Journal of Ultrasound in Medicine (subscription)...a compressed fetal heart, short lung bones, a facial cleft, flexion deformities, radial and tibial aplasia, renal agenesis, and microphthalmia.

ArQule Reports Second Quarter 2007 Financial Results  -  Aug 2, 2007
Genetic Engineering News (press release),...cancer and a potential accelerated approval study in pediatric soft tissue sarcoma, also known as MiT (microphthalmia transcription factor) tumor.

Poway boy to compete in Braille Challenge  -  Jun 15, 2007
North County Times,He was born with a condition called microphthalmia, which can be caused by several genetic mutations, according to the National Institutes of Health.

8-Year-Old Boy Needs Funds To Save His Sight  -  Apr 4, 2007
Click10.com,Alfred Cardenas has been diagnosed with bilateral microphthalmia-scelerocornea and glaucoma in both eyes. The International Kids Fund is hoping the

Although Blind, Boy Sees Future in Music  -  Apr 1, 2007
Lakeland Ledger,Matthew has microphthalmia, which means his eyes are abnormally small. Though he has been blind from birth, Matthew refused to let it interfere with his

Sally’s story  -  28 Feb 2007
RDH,Their eye conditions range from retinopathy of prematurity, cortical or cerebral visual impairment, albinism, congenital glaucoma, microphthalmia,

Second-Trimester Prenatal Diagnosis of Total Arhinia  -  Feb 26, 2007
Journal of Ultrasound in Medicine (subscription)Additionally, microphthalmia of the right eye was documented. The patient was counseled extensively regarding this potentially life-threatening condition,

Genetic Ophthalmology and the Era of Clinical Care  -  Feb 20, 2007
Journal of American Medical Association (subscription),Defects in developmental genes such as PITX2, FOXC1, PAX6, and VMD2 are responsible for multiple associated ocular anomalies such as microphthalmia,

Oxted research could aid all cancer victims  -  Dec 29, 2006
ic SurreyOnline.co.uk,Dr Colin Goding's research team presented a report on the role of a protein called microphthalmia-associated transcription factor (MITF).

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