Cutaneous T-Cell Lymphoma

This page contains recent news articles, when available, and an overview of Cutaneous T-Cell Lymphoma but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Background information on Cutaneous T-Cell Lymphoma

Cutaneous T-Cell lymphoma (CTCL) is a class of non-Hodgkin's lymphoma, which is a type of cancer of the immune system. Unlike most non-Hodgkin's lymphomas (which are generally B-cell related), CTCL is caused by a mutation of T cells. The malignant T cells in the body are pushed to the surface of the skin in a biological process used to rid the body of offending material, causing various lesions to appear on the skin. These lesions change shape as the disease progresses, typically beginning as what appears to be a rash and eventually forming plaques and tumors before metastatizing to other parts of the body.

Though there are many types of CTCL and presentation can vary from individual to individual, there are two main forms: mycosis fungoides (MF) and Sézary syndrome (SS). There is some dispute over whether SS is an advanced form of MF or a different type of CTCL entirely -- in either case, the prognosis for SS patients is substantially poorer than for those of MF.

There is no cure for CTCL, but there are a variety of treatment options available and most (about 90%) of CTCL patients are able to live relatively normal lives without serious, health-compromising complications.
News Articles on Cutaneous T-Cell Lymphoma



Allos Therapeutics Reports 2007 Results  -  Feb 27, 2008
FOXBusiness...multi-center study of PDX with vitamin B12 and folic acid supplementation in patients with relapsed or refractory cutaneous T-cell lymphoma (CTCL).

BioCryst Reports Fourth Quarter and Year End 2007 Financial ...  -  Mar 4, 2008
CNNMoney.com (press release)Forodesine HCl pivotal trial in patients with cutaneous t-cell lymphoma In October, BioCryst began enrolling patients in a pivotal, multinational trial of

Cyclacel's David Glover to Present at New York Academy of Sciences ...  -  Mar 4, 2008
FOXBusiness...modulating nucleoside analog, is in Phase 2 studies for the treatment of acute myeloid leukemia in the elderly and cutaneous T-cell lymphoma (CTCL).

BioCryst Pharmaceuticals to Announce Fourth Quarter and Fiscal ...  -  Feb 28, 2008
Earthtimes,...that the peramivir program may not be successful, that the pivotal trial with forodesine HCl in cutaneous T-cell lymphoma (CTCL) may not meet its

CuraGen and TopoTarget Report Belinostat Results Presented at ASH ...  -  Dec 10, 2007
CNNMoney.comIn a poster entitled, "Belinostat (PXD101) in Patients with Recurrent or Refractory Peripheral or Cutaneous T-Cell Lymphoma: Results of a Phase II Study,"

CuraGen and TopoTarget Report Belinostat Results Presented at ASH ...  -  Dec 10, 2007
PR Newswire (press release),..."Belinostat (PXD101) in Patients with Recurrent or Refractory Peripheral or Cutaneous T-Cell Lymphoma: Results of a Phase II Study," updated data on a

BioCryst Provides Forodesine HCl Update  -  Dec 6, 2007
CNNMoney.comDr. Duvic's presentation entitled, "Response to Oral Forodesine in Refractory Cutaneous T-Cell Lymphoma: Interim Results of a Phase I/II Study" will provide

Birmingham's BioCryst drops testing of experimental cancer drug in ...  -  Dec 7, 2007
The Birmingham News - al.com,Trials will continue on the drug's oral capsules for the treatment of a different cancer, refractory cutaneous T-cell lymphoma, BioCryst said.

BioCryst Pharma to Halt IV Drug Study  -  Dec 6, 2007
Houston Chronicle,...in the treatment of patients with refractory cutaneous T-cell lymphoma at the annual meeting of the American Society of Hematology in Atlanta on Sunday.

Cyclacel Reports Updated Phase I Sapacitabine Data at 2007 ASH Meeting  -  Dec 16, 2007
PR-USA.net (press release),A Phase II study of sapacitabine in patients with advanced cutaneous T cell lymphoma is currently ongoing. Sapacitabine is part of a deep pipeline of small

BioCryst Says Forodesine HCl As A Single Agent Or In Combination ...  -  Dec 14, 2007
Trading Markets (press release),...anti-cancer compound, forodesine HCl, exhibited clinical activity as a single oral agent in patients with advanced refractory cutaneous T-cell lymphoma.

Gloucester's cancer drug found effective against lymphoma  -  Dec 11, 2007
Pharmaceutical Business ReviewBy Staff Writer Of the 73 evaluable cutaneous T-cell lymphoma (CTCL) patients, an overall response rate of 37% (27/73) was reported, with four complete

Novartis to sell 4 new cancer drugs by 2011 -WSJ  -  Dec 4, 2007
Reuters...also aims to launch ASA404 for non-small-cell lung cancer, SOM230 for a rare group of neroendocrine tumours and LBH589 for cutaneous T-cell lymphoma.

Favrille to Report New Data on FavId (Now Specifid) at American ...  -  Dec 6, 2007
CNNMoney.com...and proprietary cost-effective manufacturing technology, including a second product candidate, FAV-201, for the treatment of cutaneous T-cell lymphoma.

BioCryst's forodesine HCI shows positive results in Phase I/II trial  -  Dec 14, 2007
CNNMoney.com...forodesine HCI demonstrated clinical activity as a single oral agent in patients with advanced refractory cutaneous T-cell lymphoma,' the company said.

Novartis aims to bring 4 new cancer drugs to market by 2011 ...  -  Dec 5, 2007
CNNMoney.com...aims to launch by 2011 are ASA404 for non-small-cell lung cancer, SOM230 for rare neuroendocrine tumours and LBH589 for cutaneous T-cell lymphoma.

Gloucester Pharmaceuticals Announces Positive Interim Results of ...  -  Dec 10, 2007
Business Wire (press release),Gloucester is conducting pivotal phase II studies of romidepsin for patients with cutaneous T-cell lymphoma (CTCL) and for patients with peripheral T-cell

Cyclacel Pharmaceuticals Provides Year End 2007 Pipeline Update ...  -  Dec 4, 2007
PR-USA.net (press release),Sapacitabine (CYC682), an orally-available, cell cycle modulating nucleoside analog, is in Phase II for the treatment of cutaneous T-cell lymphoma (CTCL)

Novartis Makes Plans to Release Four New Cancer Drugs by 2011  -  Dec 4, 2007
Wall Street Journal...to launch by 2011 are ASA404 for non-small cell lung cancer; SOM230 for a rare group of neuroendocrine tumors and LBH589 for cutaneous T-cell lymphoma.

Data Presented at 2007 ASH Meeting Demonstrate Activity of ...  -  Dec 14, 2007
CNNMoney.com...interim data from the Phase I/II clinical study of oral forodesine HCl in the treatment of subjects with refractory cutaneous T-cell lymphoma (CTCL).

Marketing Application for Vorinostat Filed in Europe for the ...  -  Dec 4, 2007
PR-USA.net (press release),...the European Medicines Agency (EMEA) for vorinostat for the treatment of advanced, refractory cutaneous T-cell lymphoma (CTCL) in the European Union.

NCI renewal grant to develop new cancer therapies  -  Dec 4, 2007
EurekAlert (press release),Recently, histone deacetylase inhibitors have been approved for the treatment of patients with cutaneous T cell lymphoma, a type of cancer of the immune

Radnor pharmaceutical company gets $14.5M in funding  -  Nov 27, 2007
Phoenix Business Journal (subscription),The company's lead drug is Clearazidea, a topical agent for cutaneous T-cell lymphoma. Clearazidea is currently in late-stage testing.

Gloucester Pharmaceuticals Announces Presentation Of Romidepsin ...  -  Dec 3, 2007
Medical News Today (press release),The Company is conducting a pivotal phase II study of romidepsin for patients with cutaneous T-cell lymphoma (CTCL) and has initiated a pivotal phase II

Merck seeks European vorinostat approval  -  Nov 27, 2007
Checkbiotech.org (press release),The company asked the European Medicines Agency to approve the drug as a treatment for advanced, refractory cutaneous T-cell lymphoma.

Amended: Novartis Expects To Commence Sales Of Four New Cancer ...  -  Dec 5, 2007
RTT News,...and LBH589, are for the treatment of non-small-cell lung cancer, a rare group of neuroendocrine tumors, and cutaneous T-cell lymphoma, respectively.

Yaupon Therapeutics Closes $14.5 Million Financing  -  Nov 28, 2007
American Venture Magazine (press release),...a topically delivered cytotoxic agent for the treatment of cutaneous T-cell lymphoma (CTCL) that is currently in pivotal clinical studies.

Merck Seeks European Vorinostat Approval  -  26 Nov 2007
Houston Chronicle,The company asked the European Medicines Agency to approve the drug as a treatment for advanced, refractory cutaneous T-cell lymphoma.

Valley funders join $14.5M round for Yaupon  -  26 Nov 2007
Bizjournals.com,The financing will support the ongoing clinical development program for a topically delivered cytotoxic agent for the treatment of cutaneous T-cell lymphoma.

Cyclacel Pharmaceuticals Provides Year End 2007 Pipeline Update ...  -  26 Nov 2007
Business Wire (press release),Sapacitabine (CYC682), an orally-available, cell cycle modulating nucleoside analog, is in Phase II for the treatment of cutaneous T-cell lymphoma (CTCL)

James River Coal Updates Sales Contract Position; Issues FY08 ...  -  26 Nov 2007
RTT News,Additionally, the company added that the Phase II study of Sapacitabine as a treatment for patients with cutaneous T-cell lymphoma or CTCL would be expanded

curagen and topotarget Announce Presentations on Belinostat at the ...  -  26 Nov 2007
PR Newswire (press release),The presentation details are as follows: Title: Belinostat (PXD101) in Patients with Recurrent or Refractory Peripheral or Cutaneous T-Cell Lymphoma:

allergies? no, conquering something much more serious  -  Nov 18, 2007
Inland Valley Daily Bulletin,...outcomes and treatment considerations. cutaneous t-cell lymphoma, accounts for about two percent of all cases of non-hodgkin's lymphoma and mostly

allos therapeutics reports third quarter 2007 financial results  -  Nov 5, 2007
CNNMoney.com...multi-center study of pdx with vitamin b12 and folic acid supplementation in patients with relapsed or refractory cutaneous t-cell lymphoma (ctcl). up

genmab to present zanolimumab and ofatumumab data at ash  -  Nov 9, 2007
PR Newswire UK (press release),...summary: genmab will present phase ii non-cutaneous t-cell lymphoma zanolimumab data and pre-clinical ofatumumab data on at the 2007 annual meeting of the

favrille announces $21.1 million registered direct offering  -  Nov 2, 2007
CNNMoney.com...including a second product candidate, fav-201, for the treatment of cutaneous t-cell lymphoma. to receive additional information on the company,

biocryst reports third quarter 2007 financial results and ...  -  Nov 8, 2007
CNNMoney.com...biocryst enrolled the first patient in a pivotal phase ii clinical trial of oral forodesine hcl in patients with cutaneous t- cell lymphoma (ctcl). the

cyclacel pharmaceuticals to present at the lazard capital markets ...  -  Nov 14, 2007
American Digital Networks (press release),...is in phase ii for the treatment of cutaneous t-cell lymphoma (ctcl) and in phase i in patients with hematologic malignancies. seliciclib (cyc202),

cyclacel pharmaceuticals reports third quarter 2007 financial ...  -  Nov 7, 2007
Business Wire (press release),...in patients with advanced cutaneous t-cell lymphoma (ctcl). the primary objective of the study is to evaluate the tolerability and response rate of

Genmab says its new HuMax-CD4 drug has unique action to treat cancer  -  Oct 15, 2007
Forbes,...a potential cancer treatment currently being developed to treat cutaneous T-cell lymphoma and non-cutaneous T-cell lymphoma, has 'unique mechanisms of

Danish shares close lower, led down by Torm, AP Moller; Norden ...  -  Oct 15, 2007
CNNMoney.comThe group said its HuMax-CD4 (zanolimumab), a potential cancer treatment currently being developed to treat cutaneous T-cell lymphoma and non-cutaneous

Favrille to Host Conference Call and Live Webcast to Discuss Third ...  -  Oct 16, 2007
CNNMoney.com...and proprietary cost-effective manufacturing technology, including a second product candidate, FAV-201, for the treatment of cutaneous T-cell lymphoma.

Genmab Shares Rise After Trial Amended, Bank Resumes Coverage  -  Oct 11, 2007
BloombergGenmab said today that Australian authorities had granted orphan drug status for HuMax-CD4's use to treat refractory cutaneous T-cell lymphoma,

BioCryst Initiates Enrollment in Pivotal Trial of Forodesine HCL ...  -  Oct 12, 2007
CNNMoney.com...enrollment of the pivotal trial of its lead oncology drug candidate, forodesine HCL, in the treatment of patients with cutaneous T-cell lymphoma (CTCL).

BioCryst Starts Cancer Study Enrollment  -  Oct 12, 2007
CNNMoney.comThe international trial will involve patients with cutaneous T-Cell lymphoma, a rare form of cancer affecting the skin. The trial is being conducted under a

CuraGen Announces Top-Line Phase II Results on Velafermin  -  Oct 11, 2007
CNNMoney.com2007 in Atlanta, GA: Belinostat Title: Belinostat (PXD101) in Patients with Recurrent or Refractory Peripheral or Cutaneous T-Cell Lymphoma: Results of

Genmab Amends HuMax-CD4 Pivotal Study in CTCL  -  Oct 12, 2007
PipelineReview.com (press release),...today it has amended the design of the ongoing pivotal study of HuMax-CD4® (zanolimumab) to treat refractory cutaneous T-cell lymphoma (CTCL) patients.

New cancer drugs could help in autoimmune disease  -  Oct 7, 2007
Scientific AmericanZolinza is approved in the United States to treat cutaneous T cell lymphoma, a type of skin cancer. Hancock said SAHA appears to bolster the work of

Favrille to Present at BIO InvestorForum  -  Oct 2, 2007
CNNMoney.com...and proprietary cost-effective manufacturing technology, including a second product candidate, FAV-201, for the treatment of cutaneous T-cell lymphoma.

Cyclacel Pharmaceuticals Acquires Specialty Pharmaceutical ...  -  Oct 8, 2007
PharmaLive.com (press release),Sapacitabine (CYC682), an orally-available, cell cycle modulating nucleoside analog, is in Phase II for the treatment of cutaneous T-cell lymphoma (CTCL)

Business brief  -  Oct 13, 2007
The Birmingham News - al.com,BioCryst Pharmaceuticals Inc. said Friday it has started enrolling cutaneous T-cell lymphoma patients in a pivotal trial of oral doses of its experimental

CuraGen Corporation Announces Appointment of Dr. Timothy M ...  -  Sep 19, 2007
CNNMoney.com...belinostat monotherapy for the treatment of cutaneous T-cell lymphoma (CTCL) or peripheral T-cell lymphoma (PTCL) in the fourth quarter of 2007.

Favrille: The Wall Street Analyst Forum Presentation Transcript  -  Sep 20, 2007
Seeking Alpha,...the treatment of cutaneous T-Cell lymphoma and recently acquired lymphoma and recently acquired a series of optimized anti-CD20 monoclonal antibodies.

Childhood friends Lira and Hernandez give cancer the boot  -  Sep 27, 2007
Eagle Tribune,...recall whether he was four or five when he was diagnosed with a rare form of cancer, at least for someone of his age, called cutaneous T-cell lymphoma.

Cyclacel Pharmaceuticals CEO Speaks About His Company  -  Sep 25, 2007
Seeking Alpha,...be further Phase I data in patients with hematological cancers or cancers of the blood and Phase II data in a cancer called cutaneous T-cell lymphoma.

Peramivir Stumbles In Phase II Influenza Study; BioCryst Falls  -  Sep 20, 2007
BioWorld Online,...based BioCryst also has a late-stage cancer drug, Fodosine, which is in Phase III testing in cutaneous T-cell lymphoma. Fodosine is partnered with Cambridge

BioCryst Pharmaceuticals down after disappointing flu trial  -  Sep 20, 2007
SmallCapInvestorAccording to Chow, BioCryst could initiate a trial for Fodosine cutaneous T-cell lymphoma during the third quarter of 2007. In the fourth quarter,

Allos Therapeutics Initiates Study of PDX in Patients with ...  -  Aug 15, 2007
CNNMoney.com..."Therapies currently used to treat cutaneous T-cell lymphoma fail to produce durable remissions in the majority of patients with advanced disease.

Favrille CEO to Present at Bear Stearns Healthcare Conference  -  Sep 4, 2007
CNNMoney.com...and proprietary cost-effective manufacturing technology, including a second product candidate, FAV-201, for the treatment of cutaneous T-cell lymphoma.

Allos Therapeutics Initiates Study Of PDX In Patients With ...  -  Aug 15, 2007
RTT News,...novel antifolate PDX or pralatrexate with vitamin B12 and folic acid supplementation in patients with relapsed or refractory cutaneous T-cell lymphoma.

Allos Therapeutics Begins Patient Enrollment In Phase 1 Study Of ...  -  Aug 15, 2007
RTT News,The company said patients with either relapsed or refractory cutaneous T- cell lymphoma will receive PDX as part of a weekly schedule for two or three weeks

Genmab gains milestone and antibody  -  Aug 14, 2007
BiopharmaReporter.com,This antibody is being developed to treat non-cutaneous T-cell lymphoma and cutaneous T-cell lymphoma. "HuMax-CD4 is a nice fit with the rest of Genmab's

Genmab Announces 2007 First Half Year Results  -  Aug 22, 2007
BourSonews,...rights to HuMax-CD4(R) (zanolimumab) from Merck Serono SA and announced final data from the HuMax-CD4 Phase II data in cutaneous T-cell lymphoma (CTCL).

Cutaneous T-cell Lymphoma On The Rise, Research Shows  -  Jul 17, 2007
Science Daily (press release)Science Daily — Cutaneous T-cell lymphoma, a rare and mysterious cancer, is on the rise, according to the first nationwide study of the disease in a decade.

Genmab reports positive phase 2 data for cancer drug candidate ...  -  Jul 2, 2007
Forbes,AS announced positive results from two phase 2 trials for its drug candidate Humax-CD4 in treatment of the cancer form CTCL (Cutaneous T Cell Lymphoma).

NCCN Updates Non-Hodgkin's Lymphoma Guidelines  -  Jun 20, 2007
Genetic Engineering News (press release),The Panel also added new guidelines for Mycosis Fungoides/Sezary Syndrome (otherwise known as Cutaneous T-Cell Lymphoma (CTCL)), a disease in which certain

Genmab 'Celebrating' Return Of Worldwide HuMax-CD4 Rights  -  Jul 1, 2007
BioWorld Online,By Jennifer Boggs Genmab A/S said it is moving full steam ahead with its late-stage HuMax-CD4 compound in cutaneous T-cell lymphoma after regaining full

Favrille Announces Data From Phase 2 Clinical Trial of FavId for ...  -  Jun 11, 2007
Earthtimes.org...and proprietary cost- effective manufacturing technology, including a second product candidate, FAV-201, for the treatment of cutaneous T-cell lymphoma.

CuraGen "market outperform"  -  Jun 15, 2007
newratings.com...clinical updates on PXD101 were extremely promising, exhibiting significant response rates in patients with advanced cutaneous T-cell lymphoma (CTCL).



Search the web for more resources on Cutaneous T-Cell Lymphoma
 
Web health.mongabay.com


Health Home | Conditions | Cancer | Medications | Surgery | Vaccines

mongabay.com


Disclaimer:

Contact a physician with regard to health concerns. Email requests for further health information will be discarded.

The materials contained on this Web site are for informational purposes only and do not constitute health or medical advice. Use of information on this site does not create or constitute any kind of agreement or contract between you and the owners or users of this site, the owners of the servers upon which it is housed, or anyone else who is in any way connected with this site.

Many links on health.mongabay.com lead to other sites. health.mongabay.com does not sponsor, endorse or otherwise approve of the materials appearing in such sites. Nor is health.mongabay.com responsible for dead or misdirected links.


COPYRIGHT 2006 MONGABAY.COM