Amyloid

This page contains recent news articles, when available, and an overview of Amyloid but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Background information on Amyloid

Amyloid describes various types of protein aggregations that share specific traits when examined microscopically. The name amyloid comes from the early mistaken identification of the substance as starch (amylum in Latin), based on crude iodine-staining techniques. For a period the scientific community debated whether or not amyloid deposits were fatty deposits or carbohydrate deposits until it was finally resolved that it was neither, rather a deposition of proteinaceous mass.

The phenotypes of genetically transmitted amyloid diseases are often inherited in an autosomal dominant fashion. Sometimes, the difference between aggressive amyloid diseases and senescent amyloid diseases is due to a mutation which makes the protein more prone to aggregation. Most commonly seen are point mutations which affect the cohesiveness of the protein and promote misfolding; other mutations cause aggregation-prone pieces of the protein to be cleaved off from the rest of the protein.
News Articles on Amyloid



New Compound Identifies Alzheimer's Disease Brain Toxins, Study Shows  -  26 Mar 2008
Science Daily (press release)Until now, the beta-amyloid deposits to which PiB binds have been confirmed, without question, only in the autopsied brains of patients afflicted with

Umbilical Cord Blood Cell Therapy May Treat Cognitive Decline Of ...  -  26 Mar 2008
Science Daily (press release)Following a series of low-dose infusions of human umbilical cord blood cells into mice with Alzheimer's-like disease, the amount of amyloid-ß and ß-amyloid

Umbilical cord blood cell therapy may reduce signs and symptoms of ...  -  26 Mar 2008
Genetic Engineering News (press release),Following a series of low-dose infusions of human umbilical cord blood cells into mice with Alzheimers-like disease, the amount of amyloid- and -amyloid

FluoroPharma Inc. Expands Technology Platform to Include Agents ...  -  26 Mar 2008
Biloxi Sun Herald,..."Our molecular imaging approach to AD includes multiple molecular compositions that target AD associated phenomena -- low acetylcholine and amyloid plaque

Pitt Researchers Discover Alzheimer's Breakthrough  -  26 Mar 2008
Pittsburgh Channel.com,Used with pet imaging, it lets researchers not only see the brain but also see where the beta-amyloid plaque deposits that kill brain cells and cause

Study links belly fat to dementia risk  -  26 Mar 2008
Los Angeles Times,One theory is that hormones and proteins released by abdominal fat spur the buildup of amyloid plaques in the brain, which are associated with Alzheimer's.

Woman's mysterious disease to be featured on Discovery Health Channel  -  26 Mar 2008
Daily News Tribune,Only 3000 to 4000 Americans are diagnosed with amyloidoses each year, according to Dr. David Seldin, director of the Amyloid Treatment and Research Center

Large strides made in preventing Alzheimer's disease  -  Mar 24, 2008
News 8 Austin,They actually correlate much better with dementia than amyloid beta plaques. What could the vaccine mean for Alzheimer's patients? Experts say they may have

Corgenix acquires rights to serum amyloid technology  -  Mar 20, 2008
Pharmaceutical Business ReviewBy Staff Writer Under the terms of the agreement, Corgenix has the exclusive rights outside of Japan to further develop the serum amyloid technology,

Scientists Discover Second Mechanism for Overproduction of Amyloid ...  -  Mar 14, 2008
Genetic Engineering News (press release),Researchers demonstrated a method to reduce the overproduction of amyloid beta (Aß) peptide in mice. The Ab peptides are cut from amyloid precursor protein

Neurochem Reveals New Initiatives For Development Of Eprodisate To ...  -  Mar 13, 2008
RTT News,...development program for its investigational product candidate, eprodisate to obtain market approval for the treatment of Amyloid A, or AA, amyloidosis.

New Drug Holds Promise for Combating Alzheimer's  -  Mar 16, 2008
Scientific AmericanBy Sarah Graham A key feature of a number of diseases¿most noticeably Alzheimer's¿is the presence of so-called amyloid deposits comprised of insoluble

Scientists unveil Alzheimer's drug target  -  Mar 15, 2008
Times of India,..."We discovered two chemical compounds that inhibit a new enzyme target, leading to reduced production of beta-amyloid and improved memory in a mouse model

Potential Alzheimer's Disease Drug Target Identified  -  Mar 14, 2008
Science Daily (press release)A hallmark sign of Alzheimer's disease, seen during autopsy of a patient's brain, is the accumulation of amyloid plaque deposits composed primarily of the

New drug shows promise for Alzheimer's  -  Mar 18, 2008
Sydney Morning Herald,The protein behaves strangely in Alzheimer's sufferers, dividing irregularly and creating a form called beta amyloid that builds up in sticky toxic clumps

Report: Alzheimer's To Hit 1-In-8 Boomers  -  Mar 18, 2008
CBS News,The most promising working theory on the origins of Alzheimer's involves the formation of a plaque called beta amyloid in people's brains.

Link Between Alzheimer's And Stroke Illuminated  -  Mar 17, 2008
Science Daily (press release)After a stroke, it is known that there is an increase in the production of the toxic amyloid beta (Aβ) peptides that are believed to cause Alzheimer’s

Paradoxical Alzheimer's Finding May Shed New Light On Memory Loss  -  Mar 12, 2008
Science Daily (press release)In previous research, lead author Veronica Galvan, PhD, prevented this cleavage in mice genetically engineered to develop the amyloid plaques and deposits

Cheers to this compound  -  Mar 8, 2008
Malaysia Star,These plaques are caused by amyloid-beta peptides. One laboratory study showed that administering resveratrol to cells decreased their secretion and cell’s

Affiris uses Definiens Technology in Fight against Alzheimer's Disease  -  Mar 18, 2008
ScienceBlog.com,The hallmark of Alzheimer's disease are deposits of aggregated beta-amyloid peptide in the brain. Beta-amyloid is removed from larger precursor protein by

Corgenix Medical Corporation executes technology licensing ...  -  Mar 19, 2008
Trading Markets (press release),The new license agreement covers new diagnostic technology for serum amyloid protein (SAP), an important serum bio-marker for cardiovascular inflammation.

Researchers use light to detect Alzheimer's  -  Mar 25, 2008
Sun-Sentinel.com,Amyloid plaques, one of the telltale signs of Alzheimer's disease, scatter light differently from normal brain tissue. What Hanlon and his colleagues showed

Researchers identify possible therapy for Alzheimer’s  -  Mar 14, 2008
Thaindian.com,The disease is characterised by accumulation of amyloid plaque deposits, noticed during autopsy of the patient’s brain. The plaque is composed primarily of

Peptide Technologies extends synthesis range with new Tribute  -  Mar 18, 2008
LabTechnologist.com,In a recent application for Alzheimer's research 12 beta amyloid (1-42) peptides were synthesised on a Symphony instrument in 12 hours whereas the microwave

Unraveling Alzheimer's secrets  -  Mar 10, 2008
Worcester Telegram,A radioactive dye called PIB (for Pittsburgh Compound B) has made it possible to use PET scans to find deposits of amyloid, an Alzheimer's-related protein,

Alzheimer's Vaccine?  -  Mar 11, 2008
WPTV,A vaccine targeting beta-amyloid protein showed promise in animal studies, but it caused serious health consequences when tested on humans.

Alzheimer's treatment attacks plaque formations  -  Mar 17, 2008
McKnight's Long Term Care News,One of the main causes of Alzheimer's is the buildup of amyloid plaque in memory centers of the brain, according to researchers. This plaque is formed when

Affiris Expands Patent Portfolio for Alzheimer’s Therapies  -  Feb 27, 2008
ScienceBlog.com,The recently patented process involves fixing receptor molecules onto a carrier material and using them to bind the beta-amyloid that can lead to the

MetLife Foundation Announces Major Awards to Scientists for ...  -  Feb 29, 2008
Business Wire (press release),Bart De Strooper, MD, Ph.D. of Belgium’s KULeuven and VIB-Institute for his work on the cell biology of the amyloid precursor protein and gamma-secretase;

Prana Biotechnology's Alzheimer's Drug Could Challenge the FDA  -  Feb 26, 2008
Seeking Alpha,A good deal of big pharma has aimed at reducing the secretion of amyloid proteins and failed. Simply put, humans need these proteins and to limit their

Anti-Hypertensives and Alzheimer's  -  Feb 26, 2008
Advance for Speech-Language Pathologists and Audiologists,In this study, Dr. Pasinetti reported that mice genetically determined to develop Alzheimer's disease beta-amyloid production and subsequent cognitive

Special Report: 'Yourself Again'  -  Mar 17, 2008
NBC5.com,Like a flu vaccine, the injections are supposed to stimulate Mallon's immune system so it'll fight off the amyloid plaques that form in her brain and are

Hormone Replacement Therapy may help to protect against Alzheimer’s  -  Mar 24, 2008
Times Online,Oestrogen has a neuroprotective effect, preventing the build-up of beta-amyloid plaques that form in the brain cells of Alzheimer’s patients,

Trigger for Alzheimer's identified  -  Mar 6, 2008
Marin Independent-Journal,Beta-amyloid plaques form when molecular cuts, caused by enzymes, occur in a protein at the points of connection between neurons.

CitiWarrants: CSL - Polish Plasma Conference  -  Mar 5, 2008
egoli.com.au,Opening Address from Dr Relkin on Alzheimer's — Dr Relkin has pioneered the use of natural human antibodies as a novel approach to anti-amyloid therapy,

Neurobiological Technologies, Buck Institute For Age Research ...  -  Mar 3, 2008
RTT News,One of the theories says AD is caused by an overabundance of amyloid-B peptide, or neurofibrillary tangles that build up inside the nerve cells.

Neurobiological Technologies, Inc. and Buck Institute Partner to ...  -  Mar 3, 2008
Earthtimes,...namely that AD is caused by either an overabundance of amyloid-B (AB) peptide, or neurofibrillary tangles that build up inside the nerve cells.

New findings about differences between teen and elderly brains ...  -  Mar 25, 2008
Santa Rosa Press Democrat,Those disruptions, called cleavage of the amyloid precursor protein, underlie the "molecular mechanism" of memory loss, he said. Elderly people -- in their

Alzheimer's Research Target May Be a Dead End  -  Feb 27, 2008
Bio-IT World,Scientists in laboratories around the world have been investigating drug candidates called amyloid inhibitors, which many experts believed could keep

EPIX Pharmaceuticals to Present Phase 2a Alzheimer’s Data at ...  -  Mar 25, 2008
Business Wire (press release),...and has led to increased levels of soluble amyloid precursor protein (sAPP) and brain-derived neurotrophic factor (BDNF) in regions of the brain known

Gammagard may reduce Alzheimer's risk  -  Mar 6, 2008
United Press InternationalThe newspaper said researchers are looking at the possibility that Gammagard can clear the brain of a protein fragment known as beta-amyloid that is thought

Natural Ways to Prevent Alzheimer’s Disease  -  Mar 10, 2008
Stop Aging Now,We know that Alzheimer’s is a build-up of two types of proteins in the brain—“plaques", which are deposits of the protein beta-amyloid that accumulate in

Health Scan: Hebrew U. makes genetic database available  -  Mar 22, 2008
Jerusalem Post,These mice also had worse learning and memory retention, and their brains contained over twice as many amyloid plaque deposits, a hallmark of Alzheimer's.

Prana shares soar on IIa Alzheimer's data  -  Feb 27, 2008
FierceBiotech,Instead of attempting to reduce the secretion of amyloid proteins associated with plaque, PBT2 attempts to stop the reaction between the proteins and zinc

Medical Breakthroughs (03/21): Hope for Alzheimer's Disease  -  Mar 24, 2008
Team 4 News,By lowering a chemical linked to Alzheimer's known as amyloid precursor protein or APP, the scientists create an ideal condition for stem cells to change

Allon's Phase II Clinical Trial Shows Statistically Significant ...  -  Feb 27, 2008
FOXBusinessScientists agree that the brains of Alzheimer's patients are characterized by two classic hallmarks of the disease: amyloid beta plaque accumulation outside

Full Text  -  Mar 13, 2008
Science Magazine (subscription)We present a structural model based on solid-state nuclear magnetic resonance restraints for amyloid fibrils from the prion-forming domain (residues 218 to

ALS Aggregates are Composed of Only One Protein: Study  -  Mar 24, 2008
MedIndia,...provided a starting point, indicating that aggregation is an intrinsic property of mutant SOD1, just like the amyloid plaques associated with Alzheimer’s.

News From The Journal Of Biological Chemistry  -  Mar 24, 2008
Medical News Today (press release),...suggesting that aggregation is an intrinsic property of mutant SOD1, very much like the amyloid plaques associated with Alzheimer's.

New Gene for Lou Gehrig's Disease Identified  -  Feb 28, 2008
Forbes,The situation is analogous to Alzheimer's Disease, he said, which is associated with beta-amyloid protein accumulation. Though relatively few Alzheimer's



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